Senior Scientist, In Vivo Antibody Discovery

Auris Health

Auris Health

United States
Posted on Thursday, February 2, 2023


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, In Vivo Antibody Discovery located in Cambridge, MA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. We pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, cardiovascular and metabolism, and pulmonary hypertension. Please visit http://www.janssenrnd.com for more information.

As a member of the Antibody Generation Group, you will be responsible for the analysis of antibody repertoire from immunized animals using NGS techniques . This will involve designing and implementing NGS experiments to generate sequence data from the antibody repertoire of the immunized animals. In addition to your primary responsibilities related to repertoire analysis with NGS, you may also be involved in mouse genetic engineering to improve antibody discovery efficiency . This may involve techniques such as CRISPR/Cas9 gene editing to introduce specific mutations or modifications to the mouse genome. A strong understanding of B-cell isolation methods such as Hybridoma technology and primary B-cell sorting will also be important. This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. Proficiency to lead within a highly coordinated, fast-paced environment will be a significant attribute. An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus. If this sounds like you, come join our team!


  • PhD in Immunology, Molecular Biology, or related field
  • Must have expertise in antibody repertoire analysis
  • Must have strong background in mouse genetics and genetic engineering techniques

Nice to have

  • Expertise in mouse genetic engineering
  • Experience in cell line engineering with CRISPR technology
  • Expertise on any of different antibody discovery platforms including hybridoma, single B cell sorting, in vitro display et al.
  • Project Management experience

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.