Post-doctoral Scientist Oncology
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Post-Doctoral Scientist in Oncology Discovery, located in Spring House, PA. Janssen is the name given to Johnson & Johnson’s global group of pharmaceutical companies. These companies market both conventional and biotech products in a broad range of therapeutic areas.
The candidate will join a dynamic oncology drug discovery team to evaluate new drugs and their mechanism of action, target biology in solid tumors, understanding how target expression is regulated, and quantitation of target expression. Areas for exploration may also include cell line screening, RNA sequencing, and CRISPR-based screening to identify mechanisms of resistance to the therapeutics.
The Oncology Discovery Post-Doctoral scientist will:
- Work collaboratively with colleagues in Oncology Discovery as well as with others in functional genomics, data sciences, and antibody development groups.
- Be strongly motivated and dedicated; show initiative and troubleshooting skills; and demonstrate the ability to work independently.
- Will design, execute, and interpret studies for testing the anti-tumor efficacy of antibody therapies in the context of in vitro models.
- Demonstrate the ability to analyze and present data in professional 'publication ready' format.
- Demonstrate the ability to contribute to various projects besides own.
- Keep up-to-date with the literature related to the field.
- Demonstrate clear and professional verbal and written communication
- Candidate will have a PhD with 0-3 years of experience in cancer biology or cancer immunology. Expertise in target validation and tumor microenvironment, including the biology of immune cells is strongly preferred.
- Ability to design, perform, interpret, troubleshoot, and report complex data is required.
- Experience with in vitro models of tumor biology, including tissue culture, is required.
- Experience with cell/molecular biology is required (some examples include; multi-color flow cytometry, cell proliferation and cytotoxicity assays (using Incucyte), capillary protein electrophoresis (Simple Western), siRNA/shRNA/CRISPR technologies, western blotting, immunoprecipitation, qRT-PCR, immunofluorescence, MSD, and ELISA).
- Experience working with primary immune cells, co-culture assays with tumor cells, and immune cell biology assays is preferred (some examples include ADCC, cytokine release, macrophage and NK cell biology, trogocytosis assays, immune cell purification and characterization).
- Experience in designing and interpreting in vivo efficacy models is preferred.
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