Description

Janssen Research & Development, LLC, a division of Johnson & Johnson’s Family of Companies is recruiting for an Associate Scientist, Downstream Process Development (Cell and Gene Therapy) located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Redefining lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The candidate for this position will take the role of leading the downstream process development for the viral/ vaccine process scale-up and tech transfer within the Cell and Gene Therapy group in Spring House, PA. The primary responsibilities will include assisting in planning and designing of downstream experiments, leading the team towards successful execution of the planned experiments, optimize the process steps to improve or enhance the quality attributes of the molecule.

Key Responsibilities:

· The Associate Scientist will assist in the development and characterization of scalable purification process, and technology transfer to the manufacturing group.

· The candidate will develop expertise with a range of downstream technologies including clarification, filtration technologies (UF/DF, Depth filters) and chromatography.

· He/ she will be responsible to set-up, operate and maintain several downstream processes related equipment’s such as AKTA, TFF system, filtration skids, etc.

· Primarily assist in the development, optimization, and scale-up of chromatography processes and filtration processes (including UF/DF, depth filtration, and sterile filtration, etc.) to improve purification yield and product quality.

· Technology transfer of the processes to internal manufacturing sites or CMOs and provide hands-on training, troubleshooting, process manufacturing support.

· Write technical report and documentation like SOP, WI and MBRs as needed.

· The candidate is expected to work in a team environment as well as contributing individually to meet project timeline and objective.

· The applicant has successfully proven technical proficiency, scientific creativity, initiative, independent thinking, project and personnel management skills and ability to collaborate with others.

Qualifications

Required:

· Bachelor’s degree in Chemical Engineering, Biomedical Engineering, Biological Science, or related field with a minimum of 2-3 years industrial experience (through internships or full-time position) as a technical contributor, or at least a Master’s Degree in similar field with 1 year of relevant industrial experience.

• Experience with downstream processes including clarification, chromatography, UF/DF, sterile filtration, and formulation for biologics drug substance development.

Preferred:

• Operation of chromatographic systems (GE AKTA, and other Unicorn based equipment)
• Ability to travel up to 10% Domestic and International

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.