Principal Scientist, In Vivo Pharmacology

Auris Health

Auris Health

United States
Posted on Thursday, September 7, 2023


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist, In Vivo Pharmacology located in Spring House, PA.

Team leader and people manager position in the In vivo Pharmacology team supervising scientists specializing in disease models for lung fibrosis and pulmonary hypertension as well as assay development and compound screening across various modalities. The Principal Scientist will use emerging developments in these fields to develop novel models/endpoints and provide technical and strategic input with the goal of progressing novel drug candidates into clinical development. The qualified candidate will work in cross-functional teams, including translational medicine, biomarkers, safety, and discovery project teams, as well as disease-specific working groups, to drive our preclinical pipeline and enable the execution of decision-making studies. The candidate will actively shape individualized discovery and pharmacology strategies for novel drug candidates, propose and develop translational animal models and promote innovative technologies to establish proof-of-concept, validate biomarkers and inform on clinical development plans.

The Principal Scientists is responsible for leading a team of in vivo scientists including people management, scientific and operational oversight. In collaboration with project teams, the scientists in in the team develop screening plans and build new models for the characterization of novel drug candidates for programs in PH and IPF. The successful candidate is responsible achieving main program deliverables through supervision of the team, by interpreting results and making recommendations for next steps, conclusions and enhancements of study designs and endpoint selection. Scientific accomplishments will be presented internally and externally to the scientific community and discussed with key opinion leaders. A background in drug discovery and/or animal models in lung disease models is required for this position.

Key Responsibilities:

  • Leveraging end-to-end drug discovery/development and disease area expertise to independently provide day-to-day coaching/guidance to individual contributors and Junior Scientists
  • Shape pipeline and preclinical strategy for novel therapeutic agents across different modalities, including small molecules, antibody therapeutics and innovative novel delivery platforms.
  • Implement novel disease models and as a in vivo or project leader working with teams to delivery proof of concept, build screening assays, drive compound selection, develop candidate profiles and validate biomarkers and PK/PD relationships.
  • Responsible for validity, reproducibility, interpretation, documentation, quality control and enhancement of preclinical study data.
  • Enhance Janssen’s reputation and innovation: Representation of Janssen externally and internally, interacting with subject matter experts in the field and maintain understanding of relevant literature and competitive landscape in related fields, plus identify new areas of research consistent with strategic direction.



  • Ph.D./MD degree in the life sciences with a post-doctoral fellowship in metabolic disease, fibrosis or immunometabolism; minimum of 5-8 years academic faculty or industry experience is required


  • Expert understanding of disease models and experience in performing pharmacological and mechanistic studies in animal models (including higher species) of pulmonary, metabolic, or fibrotic disorders is required
  • Competency in team leadership and people management is required
  • Proven record in discovery and development of novel therapeutic entities including progression and screening of novel drug candidates across various modalities, demonstration of proof of concept (POC), development and validation of novel translational models and building of PK/PD relationships for biomarker validation and human dose projections is required
  • Expert knowledge of in vivo pharmacology principles, drug metabolism, target engagement and assay development to support compound characterization and selection is required
  • Peer reviewed publication record in relevant fields, including participation in preparation of manuscripts patents, pharmacology reports and program reviews with governance committees is required
  • Excellent communication and interpersonal skills is required
  • Demonstrated experience in leading scientific projects as an in vivo or project lead or as a manager of in vivo leads in an industry setting and through cross-functional collaborations is required

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com