Scientist, Structural Biology

Auris Health

Auris Health

San Diego, CA, USA
Posted on Thursday, April 27, 2023


Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Scientist, Structural Biology, located in San Diego, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad subject areas including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding and motivated individual to join our team as Scientist, Structural Biology.

As the Scientist you will:

  • Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for therapeutic agent optimization.
  • Be responsible for determination of high-resolution structures by X-ray crystallography/ cryo-EM and communicating these results to project teams.
  • Work closely with protein scientists, biophysicists and cryo-EM scientists as part of an integrated structural biology effort.
  • Contribute to multidisciplinary Fragment-Based Lead Discovery (FBLD) efforts.
  • Contribute to enhance the structural biology scientific expertise of the group by publishing high-impact research papers, and presenting at scientific conferences, internalizing impactful technologies and platforms, and establishing academic collaborations.
  • Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.


• A minimum of Ph.D. or equivalent and postdoctoral experience in structural biology (X-ray crystallography, biophysics, protein engineering) or related field is required.
• Expertise with crystallography and cryo-EM software packages in a mixed Linux/Windows computational environment is required.
• Scientific expertise in structural biology, with strong experience in both protein crystallization and structure determination is required.
• Research experience in cryo-electron microscopy (Cryo-EM) for complex structural biology systems, with expertise in sample handling and data processing, is required.
• Strong record of external publications and presentations is required.
• Outstanding written and oral communication skills are required.
• Experience in Structure-Guided Drug Design is preferred.
• Research experience in structural biology of other modalities, including antibodies and peptides, is preferred.
• Research experience with other biophysical techniques such as MST, ITC, NMR, DSF, SPR is preferred.
• Broad knowledge of biophysics, biochemistry, molecular pharmacology, and protein sciences is preferred.
• Experience in scientific programming (Unix shells, Python) is preferred.
• Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred.

The anticipated base pay range for this position is $102,000 to $163,000.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.