A-Alpha Bio is a biotechnology company that leverages synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. Their experimental platform, Alpha Seq, allows for the rapid and quantitative measurement of millions of protein-protein binding affinities simultaneously, while their computational platform, Alpha Bind, predicts binding strength from sequence using the world’s largest protein-protein interaction database. A-Alpha Bio collaborates with leading pharmaceutical companies to inform the discovery and development of novel therapeutics, positioning itself as a key player in therapeutic discovery and optimization.

Adimab's integrated antibody discovery and optimization platform provides unprecedented speed from antigen to purified, full-length human IgGs. Adimab offers fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most aggressive standards for affinity, epitope coverage, species cross-reactivity and expressability. Adimab enables its partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.

Adyn is a precision medicine company that develops personalized birth control methods. It provides medically actionable scientific insights and empowers individuals to proactively optimize their health—from birth control to fertility and beyond. The company's first product, the Birth Control Optimization Test, is an at-home kit enabling users to collect both saliva and finger prick samples to measure hormone baseline levels and aims to assess genetic risk for blood clots and depression. Adyn's technology then synthesizes a medical biography with side effect profiles of estrogens and progestins used in hormonal contraception. Elizabeth Ruzzo headquartered the company in Seattle, Washington in 2019 and is backed by Lux Capital, M13, Civilization Ventures, Concrete Rose Capital, Y Combinator, Madrona Pioneer Fund, and Ascend VC.

Aera Therapeutics is a biotechnology company that uses its proprietary protein nanoparticle (PNP) delivery platform to help genetic medicines reach their full potential. Aera's platform, which is based on endogenous human proteins, is being developed to address the limitations of current delivery technologies and to extend the reach of genetic medicines to different tissues and applications, thereby benefiting more patients across a broader range of disease areas. In addition, Aera's licensed technology includes a therapeutic enzyme platform based on the discovery of novel, compact, and programmable gene-editing enzymes.

Aeva is a technology company specializing in advanced sensing and perception systems for autonomous navigation. Their key products, Aeries II and Atlas, utilize innovative FMCW technology to provide 4D LiDAR sensors that detect velocity and range simultaneously, enhancing the decision-making capabilities of autonomous vehicles and robots. Aeva differentiates itself with automotive-grade sensors designed for mass production, aiming to revolutionize the autonomous mobility market. The company has secured significant contracts, including a $1 billion deal with Daimler Truck, positioning it as a leader in the autonomous sensing space.

Aira is a visual interpreting service that connects individuals who are blind or low vision to professional interpreters via an app, providing secure access to visual information anytime and anywhere. The company partners with organizations to offer the app for free to their employees, students, and customers, promoting inclusivity and accessibility. Aira differentiates itself through its trained interpreters and real-time assistance, making it a vital tool for navigation, participation in daily activities, and engagement in various environments. With a growing network of access partners, Aira is positioned as a leader in the accessibility space, meeting important ADA requirements and fostering a commitment to diversity, equity, and inclusion.

Building a modern operating system for IVF, powered by artificial intelligence.

Anagenex is a biotechnology company that leverages AI-driven drug discovery to accelerate the development of new medicines. By testing billions of custom-synthesized compounds and utilizing proprietary neural networks, Anagenex iteratively refines its AI predictions to design and test new compounds at an unprecedented scale. With over 100 billion data points and the ability to conduct experiments on hundreds of millions of compounds in just one month, Anagenex aims to significantly reduce the time it takes to bring new drugs to market, addressing the urgent need for faster solutions in the pharmaceutical industry.

Anchorage Digital is a crypto platform that enables institutions to participate in digital assets through custody, staking, trading, governance, settlement, and the industry’s leading security infrastructure. Home to Anchorage Digital Bank N.A., the only federally chartered crypto bank in the U.S., Anchorage Digital also serves institutions through Anchorage Digital Singapore, which is licensed by the Monetary Authority of Singapore; Anchorage Digital New York, which holds a BitLicense from the New York Department of Financial Services; and self-custody wallet Porto by Anchorage Digital. The company is funded by leading institutions including Andreessen Horowitz, GIC, Goldman Sachs, KKR, and Visa, with its Series D valuation over $3 billion. Founded in 2017 in San Francisco, California, Anchorage Digital has offices in New York, New York; Porto, Portugal; Singapore; and Sioux Falls, South Dakota.

Anduril Industries is a defense technology company that specializes in advanced military capabilities, offering a range of products including autonomous systems, air systems, underwater vehicles, and rocket motors. Their Lattice platform integrates these technologies to provide persistent awareness and security across land, sea, and air, positioning them as a leader in the defense sector. With a focus on innovation and solving complex national security challenges, Anduril aims to support military agencies and enhance border surveillance, making them a key player in modern defense solutions.

Applied Intuition delivers an advanced driver-assistance systems (ADAS) and automated driving (AD) software toolchain, vehicle platform, and autonomy stack to help customers shorten time to market, build high-quality systems, and create next-generation consumer experiences. The company focuses on providing a unified development platform that spans the entire development cycle, from simulation to data exploration and validation, ensuring compliance with safety standards and regulations. With a flexible business model, Applied Intuition enables customers to develop in-house expertise and fosters innovation, making it a trusted partner for 18 of the top 20 global automakers.

Aptible is a Platform as a Service (PaaS) designed for startups, providing secure, reliable, and compliant hosting solutions. It automates the provisioning and management of infrastructure, allowing developers to focus on building their applications without the burden of manual configurations. With features like automatic encryption, compliance reporting, and 24/7 monitoring, Aptible ensures that companies can scale efficiently while meeting enterprise security and compliance requirements. The platform has gained traction among startups and scaling companies, positioning itself as a leader in the cloud infrastructure space.