Principal Scientist, Lead Evaluation and Cellular Pharmacology

Auris Health

Auris Health

United States
Posted on Saturday, August 26, 2023


Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Principal Scientist, Lead Evaluation and Cellular Pharmacology to be located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Discovery Technologies and Molecular Pharmacology (DTMP) team is a critical part of the Discovery Sciences organization in Janssen R&D and is committed to the delivery of high-quality chemical leads from concept to clinic as well as supporting protein and cell therapy optimization across all five Janssen Therapeutic Area discovery teams. The Principal Scientist will serve as the DTMP lead for multiple programs and will interact with diverse scientific disciplines including biochemistry, cellular pharmacology, hit identification, protein sciences and structural biology.

Within DTMP, the Lead Evaluation and Cellular Pharmacology function designs and applies rapid, innovative, and therapeutically relevant cellular assays from target concept through the lead optimization process to clinical nomination. We are seeking a highly motivated, experienced, and innovative scientific leader to drive the implementation of High Throughput (HT) cell-based assays broadly supporting our 5 therapeutic areas. The ideal candidate will have strong oral and written communication skills and the ability to connect with our partners to deliver on goals and objectives, foster an environment of collaboration, collegiality, and positive communication. S/He should demonstrate strong independence at the bench, be adept at multi-tasking, and be able to analyze and communicate data to colleagues within DTMP and with key partners such as therapeutic area biology leads. This position may also include management of associate level scientists.

Key Responsibilities:

The Principal Scientist, Lead Evaluation and Cellular Pharmacology will:

  • Implement recombinant, primary, and/or complex cell-based assays with a variety of endpoints to enable de novo lead identification from large scale screening campaigns and in support of hit triage for biochemical-based high throughput screens.
  • Conceive of and implement hit finding plans in collaboration with therapeutic area stakeholders and multidiscipline DTMP teams.
  • In collaboration with therapeutic area biology, conceive of and execute translationally relevant mechanistic cellular assays.
  • Oversee, execute, and troubleshoot weekly assays in support of medicinal chemistry efforts, assuring high-quality data analysis and reporting.
  • Exhibit an awareness of new technology advances and scientific knowledge in the field and methods to apply them to assays in the laboratory.
  • Contribute data and methods to compelling scientific presentations and reports for internal review meetings and scientific journals.



  • Ph. D. in Cell Biology and/or Physiology, Immunology, Oncology, Neuroscience or relevant field with an additional 5-8 years of pharmaceutical or biotechnology industry experience, an M.S. with 8-10 years.

Experience and Skills:


  • Possess strong solid understanding of basic molecular pharmacology including modes of target inhibition and activation is required.
  • Broad target class expertise in the establishment of robust miniaturized cell-based assays in automated plate-based formats including readouts such as fluorescence, chemiluminescence, and TR-FRET is required.
  • Demonstrated ability to construct hit finding, hit progression strategies, and possess a track record of successful high throughput lead identification is required.
  • Demonstrated ability to analyze, visualize, and interpret large (>1MM) data sets to enable hit triage is required.
  • Demonstrated ability in the application of primary cell models in the development of translational relationships with therapeutic indications is a plus.
  • Proven excellence in both written and verbal communication is required.
  • Hands-on experience with high-content imaging and/or multi-parametric flow cytometry is preferred.
  • A publication record in immunology, oncology, or neuroscience area is preferred.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.