Description

Janssen Research & Development is recruiting for a Scientist, In vivo Pharmacology located in Spring House, PA.

Scientist within the in vivo pharmacology group to support drug discovery of novel therapeutics in pulmonary hypertension (PH) and lung disease. The primary responsibility of the Scientist is to plan and perform pharmacology and mechanistic studies in preclinical models (rodents) with the goal of progressing novel drug candidates from target identification, lead optimization into clinical development. Responsibilities include study planning, hands-on study execution, data analysis and integration, troubleshooting and documentation according to best business practices.

The Scientist works in a highly collaborative environment, aligns with the teams and key stakeholders on project goals and timelines, and makes recommendations for next steps. The Scientist reviews literature, attends in-house seminars and scientific meetings to support animal model validation, make recommendations for study designs, endpoint selection, in vivo validation plans and implementation of novel animal models. The ability to pro-actively investigate, improve or adapt existing methods and techniques is required. Scientific accomplishments will be presented internally and externally to the scientific community and discussed with program teams and governance bodies.

Key Responsibilities:

• Deliver on pipeline: Under limited supervision, plans and executes studies in various preclinical animal models (rodents) to evaluate therapeutic agents in PH and lung diseases.
• Collaborates across research groups to analyze, interpret data, share results and recommends next steps.
• Pro-actively investigates, improves, or adapts existing study designs/methods/models.
• Protocol development and approval in partnership with IVS and IACUC. Responsible for validity, reproducibility, interpretation, documentation.
• Enhance Janssen’s reputation and innovation: Reviews literature and competitive landscape in related fields and develops novel ideas for models/endpoints or innovative technologies.
• Attends in-house seminars, team and departmental meetings, and regional scientific meetings as appropriate and shares ideas with team in support of project goals.
• May draft and execute peer reviewed manuscripts, technical reports and patent filings.
• May lead or teach others on team regarding processes, techniques, or tasks

Qualifications

Education:

• A Ph.D. degree (or equivalent) with 0 to 5 years of post-doctoral experience in the pharmaceutical industry or academic environment or a M.S. degree with a minimum of 8 years of experience in relevant pharmaceutical industry setting is required

Experience and Skills:

Required:

• Demonstrated understanding and experience in performing pharmacological and mechanistic studies in animal models of pulmonary and/or metabolic disorders is required
• Expertise with integrated physiological assessments in rodent models, including dosing, tissue collection and processing, hemodynamic measurements, and minor surgeries is required
• Understanding of key target pathways and advanced understanding of the overall process of drug discovery and development using various modalities, including small molecules and biologics screening in pre-clinical models is required
• Works under limited supervision with a high level of autonomy is required
• Demonstrates good oral, written, and interpersonal skills and is a strong collaborator and team player is required
• Knowledge of in vivo pharmacology principles, drug metabolism and in vivo dosing and sampling skills is required

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com