Bioinformatics Engineer - Oligonucleotide Drug Discovery

As molecular data generation and frontier model intelligence grows, new approaches to data analysis are needed across the biotech industry. Latch is building intelligent, high-performance agents for biological data analysis, empowering over 5,000 scientists across 150+ R&D labs to handle data from instrument-to-insights.

We're seeking a Bioinformatics Engineer to join our Oligonucleotide Drug Discovery working at the frontier of what artificial intelligence can achieve in biology.

About the Role

You will contribute to our technical approach to teaching agents how to understand and handle complex drug discovery and development data, working across end-to-end workflows from instrument outputs and experimental readouts to real scientific decisions. You will work as part of a team of software engineers, biologists, and drug hunters building datasets to teach these agents to reason better across:

• Genetic target and MoA selection

• ASO/siRNA drug design

• Screening and functional characterization

• Pharmacology

Requirements

• 3+ years hands-on experience with oligonucleotide (ASO/siRNA), RNA therapeutics, or related

• Experience in drug target validation or mechanism-of-action studies using functional or population genomics

• Familiarity with drug discovery and development workflows - sequence design, knockdown screening, or preclinical PK/PD

• Proficiency in AI agent use

Culture @ Latch

How we work. Genuinely flexible schedules - we just ask that you communicate when you're coming in later than usual. We care most about hard work and output. We're respectfully opinionated, it will always be us against problems, not each other. Optimize for each other's time and bring solutions, not just problems. You'll join a bench suited to your expertise, but we value cross-domain learning and interoperability across teams.

The office & perks. Waterfront office near Oracle Park, 2x free daily meals, unlimited snacks, company outings most months, and team offsites. Plus a vibrant community: cycling, soccer, figure skating, boxing, run clubs, reading clubs, martial arts, music, game nights.

Compensation & Logistics

• 1099 (or W8-BEN) contract, 40 hrs/week, no end date

• Fully performance-based pay: $120K–$180K, uncapped upside. 2x quota = 2x pay.

• 2-4 week paid ramp - full OTE from day one

• Remote (globally), hybrid, or onsite in SF (onsite preferred)

• Work authorization: OPT visa holders only (not STEM Extension)

• Onsite perks: 2x free meals/day, waterfront office (China Basin), monthly parking (based on availability)

• Candidates with all of the above qualifications + proven management skills will be eligible for more senior positions

Interview Process

Timeline: We move fast: 8–12 days from submission to offer.

1. Intro Screen - Techcnial Recruiter

2. Take-Home Project - HackerRank

3. Technical Interview - Member of Technical Staff

4. Culture Interview - C-Suite (If applicable)

5. Offer